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The Mprize, introduced in 2003, is designed to directly accelerate the development of revolutionary new life extension therapies. The prize pot continues to grow through donations; awards are made whenever a research team extends the life of mice. There are two categories of cash prizes:

  • Longevity - to the research team that breaks the world record for the oldest-ever mouse
  • Rejuvenation - to the team that develops the most successful late-onset rejuvenation that extends the life of the mice
 

The prize makes it possible to attract notable scientists from major universities like Dr. Andrzej Bartke, Southern Illinois University, who headed the team that holds the prize for longevity and Dr. Stephen Spindler, University of California, the prize holder for rejuvenation. In 2009 the first Special Mprize Lifespan Achievement Award went to Dr. Z. Dave Sharp for the successful healthy life extension of already aged mice using a pharmaceutical, rapamycin.

Meet the Competitors

Competition Rules and Application

Scientific Advisory Board: Meet the prestigious scientists who share our vision and enhance our ability to change the future of aging.

The Mprize springs from a simple truth: the greatest innovations in human history have always been fueled by three things ... competition, imagination, and the entrepreneurial spirit. The Mprize is a breakthrough approach that gives visionary competitors the resources they need to solve one of the largest humanitarian crises of our time. Meet the brilliant minds who are redefining the way we view aging.

 

Competitor Andrzej Bartke

We are working with mutant mice in which reduced release of several hormones from the pituitary or resistance to the actions of one of these hormones are associated with very impressive (approximately 50%) increase in life expectancy. These animals not only live long but are also partially protected from cancer and other age-related diseases and maintain their memory and learning ability into very late life. Our research, together with the findings from other laboratories, suggests that improved responses to insulin may explain the envious characteristics of these mutant mice. We strongly suspect that altered action of insulin in a particular organ or cell type is responsible for the delay of aging in these mice and that these alterations at a particular stage of life may be especially important. Our aim is to find how, where and when must the action of insulin be altered to produce a long-lived individual.

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